Alg8 - asparagine-linked glycosylation 8 (alpha-1,3-glucosyltransferase)

Predicted to enable alpha-1,3-mannosyltransferase activity and dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Involved in protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; midbrain; respiratory system; telencephalon; and urinary system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ih and polycystic liver disease. Orthologous to human ALG8 (ALG8 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]