Prdm12 - PR domain containing 12

Predicted to enable histone methyltransferase binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within neurogenesis and positive regulation of histone H3-K9 methylation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including future brain and nervous system. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 8. Orthologous to human PRDM12 (PR/SET domain 12). [provided by Alliance of Genome Resources, Apr 2022]