Shisa6 - shisa family member 6

Enables PDZ domain binding activity and ionotropic glutamate receptor binding activity. Involved in several processes, including excitatory chemical synaptic transmission; postsynaptic neurotransmitter receptor diffusion trapping; and regulation of signal transduction. Located in asymmetric, glutamatergic, excitatory synapse and postsynaptic density. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Is expressed in central nervous system. Orthologous to human SHISA6 (shisa family member 6). [provided by Alliance of Genome Resources, Apr 2022]