Mpl - MPL proto-oncogene, thrombopoietin receptor

Predicted to enable thrombopoietin receptor activity. Involved in several processes, including myeloid cell homeostasis; platelet aggregation; and positive regulation of platelet formation. Located in several cellular components, including cell surface; neuron projection; and neuronal cell body. Used to study myelofibrosis. Biomarker of thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor). [provided by Alliance of Genome Resources, Apr 2022]