Ptch2 - patched 2

Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Predicted to be involved in regulation of cell growth and smoothened signaling pathway. Predicted to act upstream of or within several processes, including epidermal cell fate specification; hair cycle; and positive regulation of epidermal cell differentiation. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in basal cell carcinoma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human PTCH2 (patched 2). [provided by Alliance of Genome Resources, Apr 2022]