Edn3 - endothelin 3

Predicted to enable endothelin B receptor binding activity and hormone activity. Involved in negative regulation of hormone secretion and regulation of neurotransmitter secretion. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Waardenburg syndrome type 4B; and Waardenburg's syndrome. Orthologous to human EDN3 (endothelin 3). [provided by Alliance of Genome Resources, Apr 2022]