Sash1 - SAM and SH3 domain containing 1

Predicted to enable several functions, including G-protein alpha-subunit binding activity; mitogen-activated protein kinase kinase kinase binding activity; and protein C-terminus binding activity. Predicted to be involved in positive regulation of JUN kinase activity; positive regulation of NIK/NF-kappaB signaling; and regulation of epithelial cell migration. Predicted to act upstream of or within several processes, including positive regulation of endothelial cell migration; positive regulation of signal transduction; and regulation of protein ubiquitination. Predicted to be located in cytoplasm and membrane. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Orthologous to human SASH1 (SAM and SH3 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]