Phox2b - paired-like homeobox 2b

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including nervous system development; positive regulation of cold-induced thermogenesis; and regulation of respiratory gaseous exchange by nervous system process. Predicted to act upstream of or within several processes, including nervous system development; regulation of neuron differentiation; and skeletal muscle cell differentiation. Located in nucleus. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to human PHOX2B (paired like homeobox 2B). [provided by Alliance of Genome Resources, Apr 2022]