Ncf2 - neutrophil cytosolic factor 2

Predicted to enable protein C-terminus binding activity; small GTPase binding activity; and superoxide-generating NADPH oxidase activator activity. Predicted to contribute to superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including response to hyperoxia; response to laminar fluid shear stress; and response to progesterone. Located in cytoplasm and membrane. Used to study proteinuria; renal fibrosis; and visual epilepsy. Biomarker of hypertension and obesity. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal recessive chronic granulomatous disease cytochrome b-positive type II; and rheumatoid arthritis. Orthologous to human NCF2 (neutrophil cytosolic factor 2). [provided by Alliance of Genome Resources, Apr 2022]