Tigit - T cell immunoreceptor with Ig and ITIM domains

Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in negative regulation of T cell activation; negative regulation of interleukin-12 production; and positive regulation of interleukin-10 production. Predicted to be integral component of membrane. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains). [provided by Alliance of Genome Resources, Apr 2022]