Irak1 - interleukin-1 receptor-associated kinase 1

Enables heat shock protein binding activity and protein kinase activity. Involved in several processes, including JNK cascade; cellular response to lipopolysaccharide; and positive regulation of smooth muscle cell proliferation. Located in membrane. Biomarker of brain ischemia and cognitive disorder. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]