Als2 - alsin Rho guanine nucleotide exchange factor ALS2

Predicted to enable enzyme activator activity; protein homodimerization activity; and small GTPase binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Involved in several processes, including Rac protein signal transduction; axonogenesis; and in utero embryonic development. Located in several cellular components, including dendrite; growth cone; and neuronal cell body. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 2. Orthologous to human ALS2 (alsin Rho guanine nucleotide exchange factor ALS2). [provided by Alliance of Genome Resources, Apr 2022]