Pnpla3 - patatin-like phospholipase domain containing 3

Predicted to enable several functions, including acylglycerol O-acyltransferase activity; lipase activity; and long-chain fatty acyl-CoA binding activity. Involved in cellular response to organonitrogen compound; response to sucrose; and white fat cell differentiation. Predicted to be active in cytoplasm; lipid droplet; and membrane. Biomarker of hypothyroidism and obesity. Human ortholog(s) of this gene implicated in coronary artery disease; fatty liver disease (multiple); liver disease (multiple); and type 2 diabetes mellitus. Orthologous to human PNPLA3 (patatin like phospholipase domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]