Appl2 - adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2

Predicted to enable phosphatidylinositol binding activity; phosphatidylserine binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including adiponectin-activated signaling pathway; cellular response to growth factor stimulus; and regulation of vesicle-mediated transport. Predicted to be located in cytoplasmic vesicle; nucleus; and ruffle membrane. Predicted to be active in endosome membrane. Orthologous to human APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2). [provided by Alliance of Genome Resources, Apr 2022]