Brd4 - bromodomain containing 4

Predicted to enable several functions, including P-TEFb complex binding activity; histone binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of histone H3-K36 trimethylation; regulation of intracellular signal transduction; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including histone acetylation; inner cell mass cell proliferation; and positive regulation of G2/M transition of mitotic cell cycle. Predicted to be located in condensed nuclear chromosome and nucleoplasm. Predicted to be part of cyclin/CDK positive transcription elongation factor complex. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in colon cancer and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4). [provided by Alliance of Genome Resources, Apr 2022]