Dot1l - DOT1 like histone lysine methyltransferase

Predicted to enable histone methyltransferase activity (H3-K79 specific). Predicted to be involved in several processes, including DNA damage checkpoint signaling; regulation of receptor signaling pathway via JAK-STAT; and subtelomeric heterochromatin assembly. Predicted to act upstream of or within with a negative effect on gene expression. Predicted to act upstream of or within histone H3-K79 methylation; positive regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in mixed phenotype acute leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]