Pias4 - protein inhibitor of activated STAT, 4

Enables protein C-terminus binding activity. Predicted to be involved in several processes, including positive regulation of keratinocyte apoptotic process; positive regulation of protein sumoylation; and regulation of transcription, DNA-templated. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II; negative regulation of tumor necrosis factor-mediated signaling pathway; and positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Predicted to be located in cytoplasm; nuclear matrix; and nucleoplasm. Predicted to be part of transferase complex. Orthologous to human PIAS4 (protein inhibitor of activated STAT 4). [provided by Alliance of Genome Resources, Apr 2022]