Enables signaling receptor binding activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; regulation of gene expression; and vasculogenesis. Predicted to act upstream of or within several processes, including Langerhans cell differentiation; ganglioside metabolic process; and hard palate development. Predicted to be part of integrin alphav-beta8 complex. Predicted to be active in cell surface and focal adhesion. Orthologous to human ITGB8 (integrin subunit beta 8). [provided by Alliance of Genome Resources, Apr 2022]