Spast - spastin

Predicted to enable microtubule-severing ATPase activity and tubulin binding activity. Predicted to be involved in several processes, including axonal transport; microtubule cytoskeleton organization; and protein complex oligomerization. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum tubular network; and nucleus. Predicted to be active in microtubule cytoskeleton. Predicted to colocalize with endoplasmic reticulum; endosome; and midbody. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin). [provided by Alliance of Genome Resources, Apr 2022]