Predicted to be involved in generation of catalytic spliceosome for second transesterification step and mRNA 3'-splice site recognition. Predicted to be located in nucleus. Predicted to be part of Prp19 complex and spliceosomal complex. Orthologous to several human genes including ISY1-RAB43 (ISY1-RAB43 readthrough). [provided by Alliance of Genome Resources, Apr 2022]