Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within several processes, including animal organ morphogenesis; apoptotic process; and protein ubiquitination. Predicted to be located in plasma membrane. Predicted to be part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. Orthologous to human CUL1 (cullin 1). [provided by Alliance of Genome Resources, Apr 2022]