Mapkbp1 - mitogen activated protein kinase binding protein 1

Predicted to enable kinase activity. Predicted to be involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of defense response to bacterium; and negative regulation of interleukin-8 production. Predicted to act upstream of or within positive regulation of JNK cascade. Predicted to be located in cytoplasm; mitotic spindle pole; and nuclear lumen. Human ortholog(s) of this gene implicated in nephronophthisis 20. Orthologous to human MAPKBP1 (mitogen-activated protein kinase binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]