Smarcb1 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

Predicted to enable several functions, including Tat protein binding activity; p53 binding activity; and transcription coactivator activity. Predicted to contribute to RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in several processes, including nucleosome disassembly; regulation of histone modification; and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including blastocyst hatching; negative regulation of cell population proliferation; and single stranded viral RNA replication via double stranded DNA intermediate. Located in chromatin and nucleus. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 3; atypical teratoid rhabdoid tumor; neurilemmomatosis; and rhabdoid cancer. Orthologous to human SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1). [provided by Alliance of Genome Resources, Apr 2022]