Lemd2 - LEM domain nuclear envelope protein 2

Predicted to enable chromatin DNA binding activity. Predicted to be involved in several processes, including heart formation; negative regulation of signal transduction; and protein localization to chromatin. Predicted to act upstream of or within negative regulation of MAPK cascade and skeletal muscle cell differentiation. Predicted to be located in nuclear membrane. Predicted to be integral component of nuclear inner membrane. Predicted to colocalize with chromatin; endoplasmic reticulum; and nuclear envelope. Human ortholog(s) of this gene implicated in cataract 46 juvenile-onset. Orthologous to human LEMD2 (LEM domain nuclear envelope protein 2). [provided by Alliance of Genome Resources, Apr 2022]