Sufu - SUFU negative regulator of hedgehog signaling

Predicted to enable beta-catenin binding activity and protein kinase binding activity. Predicted to be involved in cytoplasmic sequestering of transcription factor. Predicted to act upstream of with a negative effect on smoothened signaling pathway. Predicted to act upstream of or within several processes, including animal organ development; negative regulation of nitrogen compound metabolic process; and negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Predicted to be located in cilium and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling). [provided by Alliance of Genome Resources, Apr 2022]