Tmc1 - transmembrane channel-like 1

Predicted to enable mechanosensitive ion channel activity and voltage-gated calcium channel activity. Predicted to be involved in detection of mechanical stimulus involved in sensory perception of sound and vestibular reflex. Predicted to act upstream of or within several processes, including auditory receptor cell development; calcium ion transmembrane transport; and sensory perception of sound. Predicted to be located in external side of plasma membrane and stereocilium tip. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Orthologous to human TMC1 (transmembrane channel like 1). [provided by Alliance of Genome Resources, Apr 2022]