Ube3a - ubiquitin protein ligase E3A

Predicted to enable transcription coactivator activity and ubiquitin protein ligase activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; locomotory exploration behavior; and motor learning. Predicted to be located in cytosol and nucleus. Predicted to be part of proteasome complex. Used to study Angelman syndrome. Human ortholog(s) of this gene implicated in Angelman syndrome. Orthologous to human UBE3A (ubiquitin protein ligase E3A). [provided by Alliance of Genome Resources, Apr 2022]