Piezo1 - piezo-type mechanosensitive ion channel component 1

Predicted to enable identical protein binding activity and mechanosensitive cation channel activity. Predicted to be involved in several processes, including cellular response to mechanical stimulus; positive regulation of cell-cell adhesion mediated by integrin; and positive regulation of myotube differentiation. Predicted to be located in endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; and lamellipodium membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1 and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1). [provided by Alliance of Genome Resources, Apr 2022]