Spink5 - serine peptidase inhibitor, Kazal type 5

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in epidermal cell differentiation; negative regulation of antibacterial peptide production; and negative regulation of serine-type endopeptidase activity. Predicted to act upstream of or within negative regulation of serine-type peptidase activity and regulation of cell adhesion. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; epidermal lamellar body; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Netherton syndrome. Orthologous to human SPINK5 (serine peptidase inhibitor Kazal type 5). [provided by Alliance of Genome Resources, Apr 2022]