Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within protein catabolic process. Part of VCB complex. Orthologous to human CUL2 (cullin 2). [provided by Alliance of Genome Resources, Apr 2022]