Sppl3 - signal peptide peptidase like 3

Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and proteolysis. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment membrane; plasma membrane; and rough endoplasmic reticulum. Predicted to be active in Golgi-associated vesicle membrane. Predicted to be integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. Orthologous to human SPPL3 (signal peptide peptidase like 3). [provided by Alliance of Genome Resources, Apr 2022]