Ap1s1 - adaptor related protein complex 1 subunit sigma 1

Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in several processes, including cellular response to misfolded protein; protein monoubiquitination; and proteolysis involved in cellular protein catabolic process. Predicted to act upstream of or within retrograde transport, endosome to Golgi. Predicted to be located in Golgi apparatus; nucleus; and terminal bouton. Predicted to be part of AP-1 adaptor complex. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in MEDNIK syndrome. Orthologous to human AP1S1 (adaptor related protein complex 1 subunit sigma 1). [provided by Alliance of Genome Resources, Apr 2022]