Prkdc - protein kinase, DNA-activated, catalytic subunit

Predicted to enable several functions, including DNA-dependent protein kinase activity; enzyme binding activity; and nucleic acid binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of cellular senescence; and negative regulation of response to gamma radiation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of several cellular components, including DNA-dependent protein kinase-DNA ligase 4 complex; protein-DNA complex; and small-subunit processome. Predicted to be active in nucleus. Used to study severe combined immunodeficiency. Human ortholog(s) of this gene implicated in immunodeficiency 26. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]