Dock2 - dedicator of cytokinesis 2

Predicted to enable GTPase activator activity; T cell receptor binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in macropinocytosis; myeloid dendritic cell activation involved in immune response; and positive regulation of phagocytosis. Predicted to act upstream of or within several processes, including T cell activation; immunological synapse formation; and membrane raft polarization. Human ortholog(s) of this gene implicated in immunodeficiency 40. Orthologous to human DOCK2 (dedicator of cytokinesis 2). [provided by Alliance of Genome Resources, Apr 2022]