Brca2 - BRCA2, DNA repair associated

Enables single-stranded DNA binding activity. Involved in several processes, including homologous chromosome orientation involved in meiotic metaphase I plate congression; response to estradiol; and spermatogenesis. Predicted to be located in several cellular components, including centrosome; chromosome, telomeric region; and nuclear lumen. Predicted to be part of BRCA2-MAGE-D1 complex. Predicted to be active in nucleus. Used to study atrophy of testis; cancer; cataract; infertility; and osteosarcoma. Biomarker of ductal carcinoma in situ and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); brain cancer (multiple); hereditary breast ovarian cancer syndrome; melanoma (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA2 (BRCA2 DNA repair associated). [provided by Alliance of Genome Resources, Apr 2022]