Gars1 - glycyl-tRNA synthetase

Enables glycine-tRNA ligase activity. Acts upstream of or within glycyl-tRNA aminoacylation. Located in extracellular exosome and secretory granule. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; respiratory system; and urinary system. Used to study Charcot-Marie-Tooth disease type 2D. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and distal hereditary motor neuronopathy type 5A. Orthologous to human GARS1 (glycyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]