Col8a2 - collagen, type VIII, alpha 2

Predicted to be an extracellular matrix structural constituent. Acts upstream of or within camera-type eye morphogenesis and epithelial cell proliferation. Predicted to be located in basement membrane and extracellular region. Predicted to be part of collagen trimer. Predicted to be active in extracellular matrix and extracellular space. Is expressed in blood vessel; cornea endothelium; genitourinary system; and heart. Used to study Fuchs' endothelial dystrophy. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 2. Orthologous to human COL8A2 (collagen type VIII alpha 2 chain). [provided by Alliance of Genome Resources, Apr 2022]