Enables several functions, including N-acyltransferase activity; nucleic acid binding activity; and p53 binding activity. Involved in several processes, including face morphogenesis; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; and protein acylation. Acts upstream of or within several processes, including animal organ development; histone H3-K56 acetylation; and regulation of gene expression. Part of histone acetyltransferase complex and transcription regulator complex. Is expressed in several structures, including alimentary system; heart; lung; nervous system; and skin. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Orthologous to human EP300 (E1A binding protein p300). [provided by Alliance of Genome Resources, Apr 2022]