Smo - smoothened, frizzled class receptor

Predicted to enable patched binding activity. Involved in several processes, including animal organ development; regulation of animal organ morphogenesis; and regulation of gene expression. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regionalization. Located in 9+0 non-motile cilium; ciliary membrane; and cytoplasm. Is expressed in several structures, including 1st branchial arch; 4-cell stage embryo; alimentary system; central nervous system; and genitourinary system. Used to study medulloblastoma and pulmonary emphysema. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor). [provided by Alliance of Genome Resources, Apr 2022]