Ddx3x - DEAD-box helicase 3, X-linked

Predicted to enable several functions, including helicase activity; nucleic acid binding activity; and nucleoside-triphosphatase activity. Predicted to be involved in several processes, including positive regulation of type I interferon production; regulation of cellular protein metabolic process; and regulation of signal transduction. Predicted to act upstream of or within with a negative effect on primary miRNA processing. Predicted to be located in several cellular components, including centrosome; cytoplasmic stress granule; and nucleoplasm. Predicted to be part of NLRP3 inflammasome complex. Predicted to be active in P granule and nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to several human genes including DDX3X (DEAD-box helicase 3 X-linked). [provided by Alliance of Genome Resources, Apr 2022]