Arx - aristaless related homeobox

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in brain development and neuron development. Located in nucleus. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in X-linked lissencephaly 2; corpus callosum agenesis-abnormal genitalia syndrome; developmental and epileptic encephalopathy 1; and intellectual disability (multiple). Orthologous to human ARX (aristaless related homeobox). [provided by Alliance of Genome Resources, Apr 2022]