Dst - dystonin

Predicted to enable several functions, including microtubule plus-end binding activity; protein C-terminus binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including cytoskeleton organization; hemidesmosome assembly; and maintenance of cell polarity. Predicted to act upstream of or within axonogenesis; regulation of microtubule polymerization or depolymerization; and retrograde axonal transport. Predicted to be located in several cellular components, including cytoskeleton; endoplasmic reticulum; and sarcomere. Predicted to be active in several cellular components, including focal adhesion; hemidesmosome; and type III intermediate filament. Predicted to colocalize with intermediate filament. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 6. Orthologous to human DST (dystonin). [provided by Alliance of Genome Resources, Apr 2022]