Polh - DNA polymerase eta

Predicted to enable DNA-directed DNA polymerase activity. Predicted to be involved in error-prone translesion synthesis and response to UV-C. Predicted to act upstream of or within cellular response to UV-C; postreplication repair; and pyrimidine dimer repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus; replication fork; and site of double-strand break. Human ortholog(s) of this gene implicated in xeroderma pigmentosum variant type. Orthologous to human POLH (DNA polymerase eta). [provided by Alliance of Genome Resources, Apr 2022]