Setd2 - SET domain containing 2, histone lysine methyltransferase

Predicted to enable alpha-tubulin binding activity and histone methyltransferase activity (H3-K36 specific). Predicted to be involved in several processes, including defense response to other organism; nucleic acid metabolic process; and peptidyl-lysine methylation. Predicted to act upstream of or within several processes, including animal organ development; histone H3-K36 trimethylation; and tube morphogenesis. Predicted to be located in chromosome and nucleus. Human ortholog(s) of this gene implicated in carcinoma (multiple); gastrointestinal system cancer (multiple); idiopathic pulmonary fibrosis; and malignant mesothelioma. Orthologous to human SETD2 (SET domain containing 2, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]