Fli1 - Fli-1 proto-oncogene, ETS transcription factor

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including blood circulation; megakaryocyte development; and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor). [provided by Alliance of Genome Resources, Apr 2022]