Gsdmd - gasdermin D

Predicted to enable phospholipid binding activity and wide pore channel activity. Predicted to be involved in several processes, including defense response to bacterium; positive regulation of interleukin-1 beta production; and protein-containing complex assembly. Predicted to act upstream of or within cellular response to extracellular stimulus. Predicted to be located in several cellular components, including cytosol; extracellular space; and nucleoplasm. Predicted to be part of NLRP3 inflammasome complex. Orthologous to human GSDMD (gasdermin D). [provided by Alliance of Genome Resources, Apr 2022]