Cradd - CASP2 and RIPK1 domain containing adaptor with death domain

Predicted to enable death domain binding activity; protease binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; activation of cysteine-type endopeptidase activity involved in apoptotic process; and cellular response to mechanical stimulus. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain). [provided by Alliance of Genome Resources, Apr 2022]