Tdp1 - tyrosyl-DNA phosphodiesterase 1

Predicted to enable 3'-tyrosyl-DNA phosphodiesterase activity; double-stranded DNA binding activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair and single strand break repair. Predicted to act upstream of or within DNA repair. Predicted to be located in cytoplasm; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 1 with axonal neuropathy. Orthologous to human TDP1 (tyrosyl-DNA phosphodiesterase 1). [provided by Alliance of Genome Resources, Apr 2022]