Sox17 - SRY-box transcription factor 17

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Predicted to be involved in several processes, including circulatory system development; negative regulation of Wnt signaling pathway; and urogenital system development. Predicted to act upstream of or within several processes, including embryonic morphogenesis; endocardium development; and hepaticobiliary system development. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Biomarker of cholangiocarcinoma. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human SOX17 (SRY-box transcription factor 17). [provided by Alliance of Genome Resources, Apr 2022]