Atg7 - autophagy related 7

Predicted to enable Atg12 activating enzyme activity; Atg8 activating enzyme activity; and protein homodimerization activity. Involved in several processes, including cellular response to morphine; negative regulation of mitochondrial DNA replication; and negative regulation of oxidative stress-induced neuron death. Located in axon. Used to study high grade glioma. Biomarker of hypertension; myocardial infarction; neurodegenerative disease; and paraplegia. Human ortholog(s) of this gene implicated in autosomal recessive cerebellar ataxia. Orthologous to human ATG7 (autophagy related 7). [provided by Alliance of Genome Resources, Apr 2022]